Computational Biology · Cancer Genomics

Heather Rose Kates, PhD

Computational Biology Unit Lead, UF Health Cancer Institute

I build pipelines, software, and analyses that turn spatial transcriptomics, single-cell, and other high-throughput cancer genomics data into results investigators can publish, fund, and act on — work that speeds discovery and improves patient outcomes.

Heather Rose Kates
About

I'm a computational biologist and Computational Biology Unit lead with a Ph.D. in Genetics and Genomics and 5+ years developing and applying computational methods to integrate high-dimensional functional genomics and multi-omic data for cancer and immunology research. I lead the Computational Biology Unit at the University of Florida Health Cancer Institute, guiding experimental design and analytical strategy for investigators across bulk and single-cell RNA-seq, spatial transcriptomics/proteomics, ChIP-seq/CUT&RUN, WGS, and untargeted metabolomics. I build reproducible, distributed computational pipelines (Snakemake, Nextflow) across HPC and cloud infrastructure, integrate results across multiple data sources to extract meaningful biological insight, and communicate complex findings to interdisciplinary research teams.

Experience
2026–present
Computational Biology Unit Lead
UF Health Cancer Institute · Gainesville, FL
2025–2026
Bioinformatics Analyst III
UF Health Cancer Institute · Gainesville, FL
2023–2025
Bioinformatics Analyst III
UF Health Dept. of Pathology & Immunology · Gainesville, FL
2018–2023
Postdoctoral Researcher & Data Management Analyst
University of Florida · Gainesville, FL
Focus Areas
spatial transcriptomics single-cell multiomics RNA-seq ChIP-seq / CUT&RUN WES / WGS Snakemake Nextflow reproducible pipelines HPC Python R
Selected Publications
Spatially Resolved Banff Tubulitis and Glomerulitis Scoring in Kidney Allograft Biopsies via Artificial Intelligence–Based Structure Segmentation and Spatial Transcriptomics
bioRxiv, 2026
MetaWise: Combined Feature Selection and Weighting Method to Link the Serum Metabolome to Treatment Response and Survival in Glioblastoma
International Journal of Molecular Sciences, 2024
Senescent Cancer Cells Facilitate Metastasis by Adhesion-Mediated Clustering and Immune Modulation
Cancer Research (AACR), 2026
The Distinct Roles of MSH2 and MLH1 in Basal-Like Breast Cancer and Immune Modulation
bioRxiv, 2025
Full bibliography on NCBI →
Talks & Workshops
Bioinformatics Workshop – Basics of Bulk RNA-Seq Analysis
Invited Workshop Leader · UF Health Cancer Institute, Gainesville, FL · March 2026 · workshop materials →
Integrative Navigation and Analysis of Spatial Omics and Histology
Invited Workshop Leader · 2026 PCEN Virtual Scientific Symposium, Pediatric Centers of Excellence in Nephrology · March 2026
FUSION: Extracting Value from Images
Invited Speaker · Scientific Highlights: Datasets and Tools, HuBMAP Last Hurrah · Rockville, MD · June 2026